Name:
Pyridine
Synonym:
Azabenzene; Azine
CAS:
110-86-1
Section 1 - Chemical Product
MSDS Name:Pyridine
Synonym:Azabenzene; Azine
Synonym:Azabenzene; Azine
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 110-86-1 | Pyridine | 100 | 203-809-9 |
| Hazard Symbols: XN F Risk Phrases: 11 20/21/22 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Highly flammable. Harmful by inhalation, in contact with skin and if swallowed.Stench.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin. Effects may be delayed. May cause smarting of the skin and first-degree burns on short exposure. Substance is readily absorbed through the skin. Pyridine was determined not to be a skin sensitizer in guinea pigs.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause effects similar to those for inhalation exposure. Effects may be delayed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation. Prolonged exposure may result in dizziness and general weakness. Other symptoms reported with acute exposure to pyridine include nervousness, insomnia, and loss of appetite.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage.
Exposures to doses of pyridine that are too low to produce overt clinical symptoms can cause liver damage and repeated low-level exposures can cause cirrhosis. Feeding studies in rats produced blood effects like changes in clotting factors.
Highly flammable. Harmful by inhalation, in contact with skin and if swallowed.Stench.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin. Effects may be delayed. May cause smarting of the skin and first-degree burns on short exposure. Substance is readily absorbed through the skin. Pyridine was determined not to be a skin sensitizer in guinea pigs.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause effects similar to those for inhalation exposure. Effects may be delayed.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause respiratory tract irritation. Prolonged exposure may result in dizziness and general weakness. Other symptoms reported with acute exposure to pyridine include nervousness, insomnia, and loss of appetite.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage.
Exposures to doses of pyridine that are too low to produce overt clinical symptoms can cause liver damage and repeated low-level exposures can cause cirrhosis. Feeding studies in rats produced blood effects like changes in clotting factors.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Solid streams of water may be ineffective and spread material. Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Solid streams of water may be ineffective and spread material. Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Prevent spreading of vapors through sewers, ventilation systems and confined areas. Evacuate unnecessary personnel. Approach spill from upwind. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Control runoff and isolate discharged material for proper disposal.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Prevent spreading of vapors through sewers, ventilation systems and confined areas. Evacuate unnecessary personnel. Approach spill from upwind. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Control runoff and isolate discharged material for proper disposal.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapor. Use only with adequate ventilation.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. Isolate from oxidizing materials and acids.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Do not breathe vapor. Use only with adequate ventilation.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area. Isolate from oxidizing materials and acids.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Exposure Limits CAS# 110-86-1: United Kingdom, WEL - TWA: 5 ppm TWA; 16 mg/m3 TWA United Kingdom, WEL - STEL: 10 ppm STEL; 33 mg/m3 STEL United States OSHA: 5 ppm TWA; 15 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 16 mg/m3 VLE France - VME: 5 ppm VME; 15 mg/m3 VME France - VLE: 10 ppm VLE; 30 mg/m3 VLE Germany: 5 ppm TWA; 16 mg/m3 TWA Germany: Skin absorber Malaysia: 5 ppm TWA; 16 mg/m3 TWA Netherlands: 0.3 ppm MAC; 0.9 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 15 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Exposure Limits CAS# 110-86-1: United Kingdom, WEL - TWA: 5 ppm TWA; 16 mg/m3 TWA United Kingdom, WEL - STEL: 10 ppm STEL; 33 mg/m3 STEL United States OSHA: 5 ppm TWA; 15 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 16 mg/m3 VLE France - VME: 5 ppm VME; 15 mg/m3 VME France - VLE: 10 ppm VLE; 30 mg/m3 VLE Germany: 5 ppm TWA; 16 mg/m3 TWA Germany: Skin absorber Malaysia: 5 ppm TWA; 16 mg/m3 TWA Netherlands: 0.3 ppm MAC; 0.9 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 15 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless to light yellow
Odor: strong odor - fish-like - penetrating odor - nauseat
pH: 8.5 (0.2 M aq soln)
Vapor Pressure: 18 mm Hg @ 20 deg C
Viscosity: 0.95 mPa s 20 deg C
Boiling Point: 115 deg C
Freezing/Melting Point: -42 deg C
Autoignition Temperature: 482 deg C ( 899.60 deg F)
Flash Point: 17 deg C ( 62.60 deg F)
Explosion Limits, lower: 1.8%
Explosion Limits, upper: 12.4%
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: .9780
Molecular Formula: C5H5N
Molecular Weight: 79.10
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Acids, strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials:
Acids, strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 110-86-1: UR8400000 LD50/LC50:
CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500 mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = 1121 mg/kg.
Inhalation, rat: LC50 = 28500 mg/m3/1H gm/kg.
Carcinogenicity:
Pyridine - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 5/17/02 Other:
See actual entry in RTECS for complete information.
CAS# 110-86-1: UR8400000 LD50/LC50:
CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500 mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = 1121 mg/kg.
Inhalation, rat: LC50 = 28500 mg/m3/1H gm/kg.
Carcinogenicity:
Pyridine - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 5/17/02 Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: 106mg/L; 96H; Flow-through
Fish: Fathead Minnow: 106mg/L; 96H; Flow-through
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: PYRIDINE
Hazard Class: 3
UN Number: 1282
Packing Group: II
IMO
Shipping Name: PYRIDINE
Hazard Class: 3.2
UN Number: 1282
Packing Group: II
RID/ADR
Shipping Name: PYRIDINE
Hazard Class: 3
UN Number: 1282
Packing group: II
USA RQ: CAS# 110-86-1: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN F
Risk Phrases:
R 11 Highly flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28 After contact with skin, wash immediately
with...
WGK (Water Danger/Protection)
CAS# 110-86-1: 2
Canada
CAS# 110-86-1 is listed on Canadas DSL List.
CAS# 110-86-1 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 110-86-1 is listed on the TSCA inventory.
