Name:
Resin-supported Methyl Isatoic Anhydride with Isatoic Anhydride
Synonym:
None Known
CAS:
0-01-1
Section 1 - Chemical Product
MSDS Name:Resin-supported Methyl Isatoic Anhydride with Isatoic Anhydride
Synonym:None Known
Synonym:None Known
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 0-01-1 | Isatoic Anhydride (Polystyrene Support | 10-20 | 204-255-0 |
| Hazard Symbols: T Risk Phrases: 20/21 61 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation and in contact with skin. May cause harm to the unborn child.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be absorbed through the skin. If absorbed, causes symptoms similar to those of ingestion. Not expected to cause an allergic skin reaction.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation:
Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation at high concentrations may cause CNS depression and asphixiation.
Chronic:
Chronic ingestion may cause liver damage. May cause reproductive and fetal effects.
Harmful by inhalation and in contact with skin. May cause harm to the unborn child.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be absorbed through the skin. If absorbed, causes symptoms similar to those of ingestion. Not expected to cause an allergic skin reaction.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation:
Causes respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation at high concentrations may cause CNS depression and asphixiation.
Chronic:
Chronic ingestion may cause liver damage. May cause reproductive and fetal effects.
Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated. Combustible liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Containers may explode when heated. Combustible liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat and flame. Avoid breathing vapor or mist. Destroy contaminated leather clothing.
Storage:
Keep away from sources of ignition. Do not store in direct sunlight.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat and flame. Avoid breathing vapor or mist. Destroy contaminated leather clothing.
Storage:
Keep away from sources of ignition. Do not store in direct sunlight.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 0-01-1: CAS# 118-48-9: CAS# 127-19-5: United Kingdom, WEL - TWA: 10 ppm TWA; 36 mg/m3 TWA United Kingdom, WEL - STEL: 20 ppm STEL; 72 mg/m3 STEL United States OSHA: 10 ppm TWA; 35 mg/m3 TWA Belgium - TWA: 10 ppm VLE; 36 mg/m3 VLE Belgium - STEL: 20 ppm VLE; 72 mg/m3 VLE France - VME: 10 ppm VME; 35 mg/m3 VME Germany: 10 ppm TWA; 36 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 36 mg/m3 OEL Malaysia: 10 ppm TWA; 36 mg/m3 TWA Netherlands: 20 ppm STEL; 72 mg/m3 STEL Netherlands: 10 ppm MAC; 36 mg/m3 MAC Spain: 10 ppm VLA-ED; 36 mg/m3 VLA-ED Spain: 20 ppm VLA-EC; 72 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear butyl rubber gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 0-01-1: CAS# 118-48-9: CAS# 127-19-5: United Kingdom, WEL - TWA: 10 ppm TWA; 36 mg/m3 TWA United Kingdom, WEL - STEL: 20 ppm STEL; 72 mg/m3 STEL United States OSHA: 10 ppm TWA; 35 mg/m3 TWA Belgium - TWA: 10 ppm VLE; 36 mg/m3 VLE Belgium - STEL: 20 ppm VLE; 72 mg/m3 VLE France - VME: 10 ppm VME; 35 mg/m3 VME Germany: 10 ppm TWA; 36 mg/m3 TWA Germany: Skin absorber Japan: 10 ppm OEL; 36 mg/m3 OEL Malaysia: 10 ppm TWA; 36 mg/m3 TWA Netherlands: 20 ppm STEL; 72 mg/m3 STEL Netherlands: 10 ppm MAC; 36 mg/m3 MAC Spain: 10 ppm VLA-ED; 36 mg/m3 VLA-ED Spain: 20 ppm VLA-EC; 72 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear butyl rubber gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 63 deg C ( 145.40 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: Solution
Molecular Weight: 0
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, ammonia, phenols, isocyanates, cresol, nonoxidizing mineral acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, acetic acid, dimethylamine.
Hazardous Polymerization: Has not been reported
Stable under normal temperatures and pressures.
Conditions to Avoid:
Ignition sources, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, ammonia, phenols, isocyanates, cresol, nonoxidizing mineral acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, acetic acid, dimethylamine.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 0-01-1 unlisted.
CAS# 118-48-9: DM3100000 CAS# 127-19-5: AB7700000 LD50/LC50:
Not available.
Not available.
CAS# 127-19-5: Draize test, rabbit, eye: 100 mg Mild; Inhalation, mouse: LC50 = 7200 mg/m3; Inhalation, rat: LC50 = 2475 ppm/1H; Oral, mouse: LD50 = 4620 mg/kg; Oral, rat: LD50 = 4300 mg/kg; Skin, rabbit: LD50 = 2240 mg/kg; Skin, rat: LD50 = >2 gm/kg.
Inhalation 1 hour, LC50, female rat: 8.81 mg/L (data from DuPont).
Carcinogenicity:
Isatoic Anhydride, Sodium Salt - Not listed by ACGIH, IARC, or NTP.
Isatoic Anhydride (Polystyrene Supported) - Not listed by ACGIH, IARC, or NTP.
N,N-Dimethylacetamide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 0-01-1 unlisted.
CAS# 118-48-9: DM3100000 CAS# 127-19-5: AB7700000 LD50/LC50:
Not available.
Not available.
CAS# 127-19-5: Draize test, rabbit, eye: 100 mg Mild; Inhalation, mouse: LC50 = 7200 mg/m3; Inhalation, rat: LC50 = 2475 ppm/1H; Oral, mouse: LD50 = 4620 mg/kg; Oral, rat: LD50 = 4300 mg/kg; Skin, rabbit: LD50 = 2240 mg/kg; Skin, rat: LD50 = >2 gm/kg.
Inhalation 1 hour, LC50, female rat: 8.81 mg/L (data from DuPont).
Carcinogenicity:
Isatoic Anhydride, Sodium Salt - Not listed by ACGIH, IARC, or NTP.
Isatoic Anhydride (Polystyrene Supported) - Not listed by ACGIH, IARC, or NTP.
N,N-Dimethylacetamide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: 1500 mg/L; 96hr LC50; Flow-through
Fish: Fathead Minnow: 1500 mg/L; 96hr LC50; Flow-through
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: Toxic Liquids, organic, n.o.s.
Hazard Class: 6.1
UN Number: 2810
Packing Group: III
IMO
Shipping Name: Toxic Liquids, organic, n.o.s.
Hazard Class: 6.1
UN Number: 2810
Packing Group: III
RID/ADR
Shipping Name: Toxic Liquids, organic, n.o.s.
Hazard Class: 6.1
UN Number: 2810
Packing group:
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 61 May cause harm to the unborn child.
R 20/21 Harmful by inhalation and in contact with
skin.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 0-01-1: No information available.
CAS# 118-48-9: 1
CAS# 127-19-5: 1
Canada
CAS# 118-48-9 is listed on Canadas NDSL List.
CAS# 127-19-5 is listed on Canadas DSL List.
CAS# 0-01-1 is not listed on Canadas Ingredient Disclosure List.
CAS# 118-48-9 is not listed on Canadas Ingredient Disclosure List.
CAS# 127-19-5 is listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 0-01-1 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 118-48-9 is listed on the TSCA inventory.
CAS# 127-19-5 is listed on the TSCA inventory.
