Name:
Saturated Phenol pH 6.6/7.9
Synonym:
Phenol buffer solution
CAS:
77-86-1
Section 1 - Chemical Product
MSDS Name:Saturated Phenol pH 6.6/7.9
Synonym:Phenol buffer solution
Synonym:Phenol buffer solution
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 77-86-1 | Tris (hydroxymethyl) aminomethane | N/A | 201-064-4 |
| Hazard Symbols: T Risk Phrases: 34 24/25 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns. Toxic in contact with skin and if swallowed.Corrosive.Combustible liquid.
Potential Health Effects
Eye:
Contact with liquid or vapor causes severe burns and possible irreversible eye damage.
Skin:
Harmful if absorbed through the skin. Causes severe skin irritation and burns.
Ingestion:
Harmful if swallowed. Symptoms may include: headache, excitement, fatigue, nausea, vomiting, stupor, and coma. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Causes digestive tract burns with immediate pain, swelling of the throat, convulsions, and possible coma.
Inhalation:
Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May be fatal if exposed to high concentrations. May also cause pallor, loss of appetite, nausea, vomiting, diarrhea, weakness, darkened urine, headache, sweating, convulsions, cyanosis (bluish skin due to deficient oxygenation of the blood), unconsciousness, fatigue, pulmonary edema & coma.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. Chronic ingestion may cause effects similar to those of acute ingestion. May cause liver and kidney damage. Repeated skin contact may cause dermatitis with dark pigmentation of the skin.
Causes burns. Toxic in contact with skin and if swallowed.Corrosive.Combustible liquid.
Potential Health Effects
Eye:
Contact with liquid or vapor causes severe burns and possible irreversible eye damage.
Skin:
Harmful if absorbed through the skin. Causes severe skin irritation and burns.
Ingestion:
Harmful if swallowed. Symptoms may include: headache, excitement, fatigue, nausea, vomiting, stupor, and coma. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Causes digestive tract burns with immediate pain, swelling of the throat, convulsions, and possible coma.
Inhalation:
Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. May be fatal if exposed to high concentrations. May also cause pallor, loss of appetite, nausea, vomiting, diarrhea, weakness, darkened urine, headache, sweating, convulsions, cyanosis (bluish skin due to deficient oxygenation of the blood), unconsciousness, fatigue, pulmonary edema & coma.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. Chronic ingestion may cause effects similar to those of acute ingestion. May cause liver and kidney damage. Repeated skin contact may cause dermatitis with dark pigmentation of the skin.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. SPEEDY ACTION IS CRITICAL! Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. SPEEDY ACTION IS CRITICAL! Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Use water spray to keep fire-exposed containers cool. Combustible liquid. May be ignited by heat, sparks, and flame. Containers may explode when heated.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam. Cool containers with flooding quantities of water until well after fire is out.
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Use water spray to keep fire-exposed containers cool. Combustible liquid. May be ignited by heat, sparks, and flame. Containers may explode when heated.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam. Cool containers with flooding quantities of water until well after fire is out.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Use with adequate ventilation. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 77-86-1: CAS# 108-95-2: United Kingdom, WEL - TWA: 2 ppm TWA United Kingdom, WEL - STEL: 6 ppm STEL United States OSHA: 5 ppm TWA; 19 mg/m3 TWA Belgium - TWA: 2 ppm VLE; 7.8 mg/m3 VLE France - VME: 5 ppm VME; 19 mg/m3 VME Germany: 5 ppm TWA; 19 mg/m3 TWA Germany: Skin absorber Japan: 5 ppm OEL; 19 mg/m3 OEL Malaysia: 5 ppm TWA; 15 mg/m3 TWA Netherlands: 2 ppm MAC; 8 mg/m3 MAC Russia: 0.3 mg/m3 TWA Spain: 2 ppm VLA-ED; 8 mg/m3 VLA-ED CAS# 6381-92-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 77-86-1: CAS# 108-95-2: United Kingdom, WEL - TWA: 2 ppm TWA United Kingdom, WEL - STEL: 6 ppm STEL United States OSHA: 5 ppm TWA; 19 mg/m3 TWA Belgium - TWA: 2 ppm VLE; 7.8 mg/m3 VLE France - VME: 5 ppm VME; 19 mg/m3 VME Germany: 5 ppm TWA; 19 mg/m3 TWA Germany: Skin absorber Japan: 5 ppm OEL; 19 mg/m3 OEL Malaysia: 5 ppm TWA; 15 mg/m3 TWA Netherlands: 2 ppm MAC; 8 mg/m3 MAC Russia: 0.3 mg/m3 TWA Spain: 2 ppm VLA-ED; 8 mg/m3 VLA-ED CAS# 6381-92-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHAs eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: Not available.
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 175 deg F ( 79.44 deg C)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula:
Molecular Weight: 0
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Acids (mineral, non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic acid, phosphoric acid), acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), azo, diazo, and hydrazines (e.g. dimethyl hydrazine, hydrazine, methyl hydrazine), isocyanates (e.g. methyl isocyanate), metals (alkali and alkaline, e.g. cesium, potassium, sodium), nitrides (e.g. potassium nitride, sodium nitride), peroxides and hydroperoxides (organic, e.g. acetyl peroxide, benzoyl peroxide, butyl peroxide, methyl ethyl ketone peroxide), epoxides (e.g. butyl glycidyl ether), explosives (e.g. ammonium nitrate, hydrazoic acid, sodium azide), polymerizable compounds (e.g. butadiene, methyl acrylate, styrene, vinyl chloride), oxidizing agents (strong, e.g.
bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), reducing agents (strong, e.g. aluminum carbide, chlorosilane, hydrogen phosphide, lithium hydride), water reactive substances (e.g.
acetic anyhdride, alkyl.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Stable.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Acids (mineral, non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic acid, phosphoric acid), acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), azo, diazo, and hydrazines (e.g. dimethyl hydrazine, hydrazine, methyl hydrazine), isocyanates (e.g. methyl isocyanate), metals (alkali and alkaline, e.g. cesium, potassium, sodium), nitrides (e.g. potassium nitride, sodium nitride), peroxides and hydroperoxides (organic, e.g. acetyl peroxide, benzoyl peroxide, butyl peroxide, methyl ethyl ketone peroxide), epoxides (e.g. butyl glycidyl ether), explosives (e.g. ammonium nitrate, hydrazoic acid, sodium azide), polymerizable compounds (e.g. butadiene, methyl acrylate, styrene, vinyl chloride), oxidizing agents (strong, e.g.
bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), reducing agents (strong, e.g. aluminum carbide, chlorosilane, hydrogen phosphide, lithium hydride), water reactive substances (e.g.
acetic anyhdride, alkyl.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 77-86-1: TY2900000 CAS# 108-95-2: SJ3325000 CAS# 6381-92-6: AH4410000 LD50/LC50:
CAS# 77-86-1: Oral, rat: LD50 = 5900 mg/kg.
CAS# 108-95-2: Draize test, rabbit, eye: 5 mg Severe; Draize test, rabbit, skin: 500 mg/24H Severe; Draize test, rabbit, skin: 100 mg Mild; Inhalation, mouse: LC50 = 177 mg/m3; Inhalation, mouse: LC50 = 177 mg/m3/4H; Inhalation, rat: LC50 = 316 mg/m3; Inhalation, rat: LC50 = 316 mg/m3/4H; Oral, mouse: LD50 = 270 mg/kg; Oral, rat: LD50 = 317 mg/kg; Oral, rat: LD50 = 512 mg/kg; Skin, rabbit: LD50 = 630 mg/kg; Skin, rat: LD50 = 669 mg/kg; Skin, rat: LD50 = 1500 mg/kg.
CAS# 6381-92-6.
Carcinogenicity:
Tris (hydroxymethyl) aminomethane - Not listed by ACGIH, IARC, or NTP.
Phenol - Not listed by ACGIH, IARC, or NTP.
Disodium EDTA dihydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 77-86-1: TY2900000 CAS# 108-95-2: SJ3325000 CAS# 6381-92-6: AH4410000 LD50/LC50:
CAS# 77-86-1: Oral, rat: LD50 = 5900 mg/kg.
CAS# 108-95-2: Draize test, rabbit, eye: 5 mg Severe; Draize test, rabbit, skin: 500 mg/24H Severe; Draize test, rabbit, skin: 100 mg Mild; Inhalation, mouse: LC50 = 177 mg/m3; Inhalation, mouse: LC50 = 177 mg/m3/4H; Inhalation, rat: LC50 = 316 mg/m3; Inhalation, rat: LC50 = 316 mg/m3/4H; Oral, mouse: LD50 = 270 mg/kg; Oral, rat: LD50 = 317 mg/kg; Oral, rat: LD50 = 512 mg/kg; Skin, rabbit: LD50 = 630 mg/kg; Skin, rat: LD50 = 669 mg/kg; Skin, rat: LD50 = 1500 mg/kg.
CAS# 6381-92-6.
Carcinogenicity:
Tris (hydroxymethyl) aminomethane - Not listed by ACGIH, IARC, or NTP.
Phenol - Not listed by ACGIH, IARC, or NTP.
Disodium EDTA dihydrate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Daphnia: Fathead Minnow: EC50=4.0 mg/l; 96-hour; cas#108-95-2Daphnia: Fathead Minnow: EC50=12.0 mg/l; 48-hour; cas#108-95-2No data
Daphnia: Fathead Minnow: EC50=4.0 mg/l; 96-hour; cas#108-95-2Daphnia: Fathead Minnow: EC50=12.0 mg/l; 48-hour; cas#108-95-2No data
Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
USA RQ: CAS# 108-95-2: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 24/25 Toxic in contact with skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 28 After contact with skin, wash immediately
with...
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 77-86-1: 1
CAS# 108-95-2: 2
CAS# 6381-92-6: 2
Canada
CAS# 77-86-1 is listed on Canadas DSL List.
CAS# 108-95-2 is listed on Canadas DSL List.
CAS# 6381-92-6 is listed on Canadas DSL List.
CAS# 77-86-1 is not listed on Canadas Ingredient Disclosure List.
CAS# 108-95-2 is listed on Canadas Ingredient Disclosure List.
CAS# 6381-92-6 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 77-86-1 is listed on the TSCA inventory.
CAS# 108-95-2 is listed on the TSCA inventory.
CAS# 6381-92-6 is not on the TSCA Inventory because it is a hydrate.
It is considered to be listed if the CAS number for the anhydrous form
is on the inventory (40CFR720.3(u)(2)).
