Name:
Sodium Methoxide 30 wt% Solution in Methanol
Synonym:
None
CAS:
67-56-1
Section 1 - Chemical Product
MSDS Name:Sodium Methoxide 30 wt% Solution in Methanol
Synonym:None
Synonym:None
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
| CAS# | Chemical Name | emsds | EINECS# |
| 67-56-1 | Methyl alcohol | 70.0 | 200-659-6 |
| Hazard Symbols: T Risk Phrases: 10 14 23/24/25 34 39/23/24/25 |
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Reacts violently with water. Toxic by inhalation, in contact with skin and if swallowed. Causes burns. Toxic : danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.Water-reactive.
Potential Health Effects
Eye:
Causes eye burns. Inhalation, ingestion or skin absorption of methanol can cause significant disturbances in vision, including blindness.
Skin:
Harmful if absorbed through the skin. Causes skin burns. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. Methanol can be absorbed through the skin, producing systemic effects that include visual disturbances.
Ingestion:
Harmful if swallowed. May be fatal or cause blindness if swallowed.
Causes gastrointestinal tract burns. May cause kidney damage. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation:
Causes chemical burns to the respiratory tract. Methanol is toxic and can very readily form extremely high vapor concentrations at room temperature. Inhalation is the most common route of occupational exposure. At first, methanol causes CNS depression with nausea, headache, vomiting, dizziness and incoordination. A time period with no obvious symptoms follows (typically 8-24 hrs). This latent period is followed by metabolic acidosis and severe visual effects which may include reduced reactivity and/or increased sensitivity to light, blurred, double and/or snowy vision, and blindness. Depending on the severity of exposure and the promptness of treatment, survivors may recover completely or may have permanent blindness, vision disturbances and/or nervous system effects.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic exposure may cause effects similar to those of acute exposure.
Methanol is only very slowly eliminated from the body. Because of this slow elimination, methanol should be regarded as a cumulative poison. Though a single exposure may cause no effect, daily exposures may result in the accumulation of a harmful amount. Methanol has produced fetotoxicity in rats and teratogenicity in mice exposed by inhalation to high concentrations that did not produce significant maternal toxicity.
Flammable. Reacts violently with water. Toxic by inhalation, in contact with skin and if swallowed. Causes burns. Toxic : danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.Water-reactive.
Potential Health Effects
Eye:
Causes eye burns. Inhalation, ingestion or skin absorption of methanol can cause significant disturbances in vision, including blindness.
Skin:
Harmful if absorbed through the skin. Causes skin burns. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. Methanol can be absorbed through the skin, producing systemic effects that include visual disturbances.
Ingestion:
Harmful if swallowed. May be fatal or cause blindness if swallowed.
Causes gastrointestinal tract burns. May cause kidney damage. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure.
Inhalation:
Causes chemical burns to the respiratory tract. Methanol is toxic and can very readily form extremely high vapor concentrations at room temperature. Inhalation is the most common route of occupational exposure. At first, methanol causes CNS depression with nausea, headache, vomiting, dizziness and incoordination. A time period with no obvious symptoms follows (typically 8-24 hrs). This latent period is followed by metabolic acidosis and severe visual effects which may include reduced reactivity and/or increased sensitivity to light, blurred, double and/or snowy vision, and blindness. Depending on the severity of exposure and the promptness of treatment, survivors may recover completely or may have permanent blindness, vision disturbances and/or nervous system effects.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic exposure may cause effects similar to those of acute exposure.
Methanol is only very slowly eliminated from the body. Because of this slow elimination, methanol should be regarded as a cumulative poison. Though a single exposure may cause no effect, daily exposures may result in the accumulation of a harmful amount. Methanol has produced fetotoxicity in rats and teratogenicity in mice exposed by inhalation to high concentrations that did not produce significant maternal toxicity.
Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Ethanol may inhibit methanol metabolism.
Antidote: Ethanol may inhibit methanol metabolism.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Ethanol may inhibit methanol metabolism.
Antidote: Ethanol may inhibit methanol metabolism.
Section 5 - FIRE FIGHTING MEASURES
General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Flammable liquid and vapor.
May be ignited by heat, sparks, and flame. Vapors may form an explosive mixture with air. Containers may explode when heated.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER!
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Flammable liquid and vapor.
May be ignited by heat, sparks, and flame. Vapors may form an explosive mixture with air. Containers may explode when heated.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER!
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Do not allow contact with water.
Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Do not allow contact with water.
Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use only under a chemical fume hood.
Exposure Limits CAS# 67-56-1: United Kingdom, WEL - TWA: 200 ppm TWA; 266 mg/m3 TWA United Kingdom, WEL - STEL: 250 ppm STEL; 333 mg/m3 STEL United States OSHA: 200 ppm TWA; 260 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 266 mg/m3 VLE Belgium - STEL: 250 ppm VLE; 333 mg/m3 VLE France - VME: 200 ppm VME; 260 mg/m3 VME France - VLE: 1000 ppm VLE; 1300 mg/m3 VLE Germany: 200 ppm TWA; 270 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 260 mg/m3 OEL Malaysia: 200 ppm TWA; 262 mg/m3 TWA Netherlands: 200 ppm MAC; 260 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 200 ppm VLA-ED; 266 mg/m3 VLA-ED Spain: 250 ppm VLA-EC; 333 mg/m3 VLA-EC CAS# 124-41-4: Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Use only under a chemical fume hood.
Exposure Limits CAS# 67-56-1: United Kingdom, WEL - TWA: 200 ppm TWA; 266 mg/m3 TWA United Kingdom, WEL - STEL: 250 ppm STEL; 333 mg/m3 STEL United States OSHA: 200 ppm TWA; 260 mg/m3 TWA Belgium - TWA: 200 ppm VLE; 266 mg/m3 VLE Belgium - STEL: 250 ppm VLE; 333 mg/m3 VLE France - VME: 200 ppm VME; 260 mg/m3 VME France - VLE: 1000 ppm VLE; 1300 mg/m3 VLE Germany: 200 ppm TWA; 270 mg/m3 TWA Germany: Skin absorber Japan: 200 ppm OEL; 260 mg/m3 OEL Malaysia: 200 ppm TWA; 262 mg/m3 TWA Netherlands: 200 ppm MAC; 260 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 200 ppm VLA-ED; 266 mg/m3 VLA-ED Spain: 250 ppm VLA-EC; 333 mg/m3 VLA-EC CAS# 124-41-4: Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate protective gloves and clothing to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: colorless to light yellow
Odor: alcohol-like
pH: Not available.
Vapor Pressure: 50 mmHg @ 20 C
Viscosity: mPas 20 deg C
Boiling Point: 93 deg C @ 760.00mm Hg
Freezing/Melting Point: 1 - 5 deg C
Autoignition Temperature: 240 deg C ( 464.00 deg F)
Flash Point: 33 deg C ( 91.40 deg F)
Explosion Limits, lower: 5.50 vol %
Explosion Limits, upper: 44.00 vol %
Decomposition Temperature:
Solubility in water: Reacts.
Specific Gravity/Density: .9450g/cm3
Molecular Formula: Not applicable.
Molecular Weight:
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Reacts violently with water.
Conditions to Avoid:
Incompatible materials, ignition sources, contact with water, evaporating to near dryness.
Incompatibilities with Other Materials:
Metals, acids, oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, sodium oxide.
Hazardous Polymerization: Has not been reported.
Reacts violently with water.
Conditions to Avoid:
Incompatible materials, ignition sources, contact with water, evaporating to near dryness.
Incompatibilities with Other Materials:
Metals, acids, oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, sodium oxide.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 67-56-1: PC1400000 CAS# 124-41-4: PC3570000 LD50/LC50:
CAS# 67-56-1: Draize test, rabbit, eye: 40 mg Moderate; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, rabbit: LC50 = 81000 mg/m3/14H; Inhalation, rat: LC50 = 64000 ppm/4H; Oral, mouse: LD50 = 7300 mg/kg; Oral, rabbit: LD50 = 14200 mg/kg; Oral, rat: LD50 = 5600 mg/kg; Skin, rabbit: LD50 = 15800 mg/kg.
CAS# 124-41-4: Oral, rat: LD50 = 2037 mg/kg.
Carcinogenicity:
Methyl alcohol - Not listed by ACGIH, IARC, or NTP.
Sodium methylate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
CAS# 67-56-1: PC1400000 CAS# 124-41-4: PC3570000 LD50/LC50:
CAS# 67-56-1: Draize test, rabbit, eye: 40 mg Moderate; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, rabbit: LC50 = 81000 mg/m3/14H; Inhalation, rat: LC50 = 64000 ppm/4H; Oral, mouse: LD50 = 7300 mg/kg; Oral, rabbit: LD50 = 14200 mg/kg; Oral, rat: LD50 = 5600 mg/kg; Skin, rabbit: LD50 = 15800 mg/kg.
CAS# 124-41-4: Oral, rat: LD50 = 2037 mg/kg.
Carcinogenicity:
Methyl alcohol - Not listed by ACGIH, IARC, or NTP.
Sodium methylate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Rainbow trout: LC50 = 13-68 mg/L; 96 Hr.; 12 degrees CFish: Fathead Minnow: LC50 = 29400 mg/L; 96 Hr.; 25 degrees C, pH 7.63Fish: Rainbow trout: LC50 = 8000 mg/L; 48 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 51,000-320,000 mg/L; 30 minutes; Microtox test
Fish: Rainbow trout: LC50 = 13-68 mg/L; 96 Hr.; 12 degrees CFish: Fathead Minnow: LC50 = 29400 mg/L; 96 Hr.; 25 degrees C, pH 7.63Fish: Rainbow trout: LC50 = 8000 mg/L; 48 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 51,000-320,000 mg/L; 30 minutes; Microtox test
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
IATA
Shipping Name: SODIUM METHYLATE SOLUTION
Hazard Class: 3 (8)
UN Number: 1289
Packing Group: III
IMO
Shipping Name: SODIUM METHYLATE SOLUTION
Hazard Class: 3.3 (8)
UN Number: 1289
Packing Group: III
RID/ADR
Shipping Name: SODIUM METHYLATE SOLUTION
Hazard Class: 3
UN Number: 1289
Packing group: III
USA RQ: CAS# 67-56-1: 5000 lb final RQ; 2270 kg final RQ
USA RQ: CAS# 124-41-4: 1000 lb final RQ; 454 kg final RQ
Section 15 - REGULATORY INFORMATION
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 10 Flammable.
R 14 Reacts violently with water.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 34 Causes burns.
R 39/23/24/25 Toxic : danger of very serious
irreversible effects through inhalation, in contact
with skin and if swallowed.
Safety Phrases:
S 7/8 Keep container tightly closed and dry.
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37 Wear suitable protective clothing and
gloves.
S 43A In case of fire, use dry chemical (never use
water).
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 67-56-1: 1
CAS# 124-41-4: 1
Canada
CAS# 67-56-1 is listed on Canadas DSL List.
CAS# 124-41-4 is listed on Canadas DSL List.
CAS# 67-56-1 is listed on Canadas Ingredient Disclosure List.
CAS# 124-41-4 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 67-56-1 is listed on the TSCA inventory.
CAS# 124-41-4 is listed on the TSCA inventory.
