MSDS Name:Xylenes mixed isomers with ethylbenzene (Flash Point 26.1C / 79F;
Synonym:Dimethylbenzene; Methyltoluene

EMERGENCY OVERVIEW
Flammable. Harmful by inhalation and in contact with skin.
Irritating to eyes and skin.
Potential Health Effects
Eye:
Splashes of xylene in human eyes generally cause transient superficial injury.
Skin:
May be harmful if absorbed through the skin. Xylene contact causes defatting of the skin with irritation, dryness, and cracking.
Blistering may occur, particularly if exposure to concentrated xylene is prolonged and the exposed area of skin is occluded.
Ingestion:
Aspiration hazard. May cause irritation of the digestive tract. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea.
Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal.
Inhalation:
Causes respiratory tract irritation. Irritation may lead to chemical pneumonitis and pulmonary edema. Odor thresholds ranging from 0.07 to 40 ppm have been reported for xylenes. Inhalation overexposure may lead to central nervous system depression, producing effects such as dizziness, headache, confusion, incoordination, nausea, weakness, and loss of consciousness. Extreme exposures may cause other CNS effects including death.
Chronic:
Chronic exposure to xylene may cause defatting dermatitis, reversible eye damage, dyspnea (labored breathing), confusion, dizziness, apprehension, memory loss, headache, tremors, weakness, anorexia, nausea, ringing in the ears, irritability, thirst, mild changes in liver function, kidney impairment, anemia, and hyperplasia, but not destruction, of the bone marrow.

Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
Potential for aspiration if swallowed. Get medical aid immediately.
Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Flammable liquid and vapor. Vapors may form an explosive mixture with air. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. This liquid floats on water and may travel to a source of ignition and spread fire. May accumulate static electricity.
Extinguishing Media:
Water may be ineffective. This material is lighter than water and insoluble in water. The fire could easily be spread by the use of water in an area where the water cannot be contained. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces. U.S. regulations require reporting spills and releases to soil, water and air in excess of reportable quantities. This material creates a fire hazard because it floats on water. If possible, try to contain floating material.

Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Avoid breathing vapor or mist.
Storage:
Keep away from sources of ignition. Keep container closed when not in use. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.

Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Ventilation fans and other electrical service must be non-sparking and have an explosion-proof design.
Exposure Limits CAS# 100-41-4: United Kingdom, WEL - TWA: 100 ppm TWA; 441 mg/m3 TWA United Kingdom, WEL - STEL: 125 ppm STEL; 552 mg/m3 STEL United States OSHA: 100 ppm TWA; 435 mg/m3 TWA Belgium - TWA: 100 ppm VLE; 442 mg/m3 VLE Belgium - STEL: 125 ppm VLE; 551 mg/m3 VLE France - VME: 100 ppm VME; 435 mg/m3 VME Germany: 100 ppm TWA; 440 mg/m3 TWA Germany: Skin absorber Japan: 50 ppm OEL; 217 mg/m3 OEL Malaysia: 100 ppm TWA; 434 mg/m3 TWA Netherlands: 50 ppm MAC; 215 mg/m3 MAC Russia: 50 mg/m3 TWA Spain: 100 ppm VLA-ED; 441 mg/m3 VLA-ED Spain: 200 ppm VLA-EC; 884 mg/m3 VLA-EC CAS# 1330-20-7: United Kingdom, WEL - TWA: 50 ppm TWA; 220 mg/m3 TWA United Kingdom, WEL - STEL: 100 ppm STEL; 441 mg/m3 STEL United States OSHA: 100 ppm TWA; 435 mg/m3 TWA Belgium - TWA: 50 ppm VLE; 221 mg/m3 VLE Belgium - STEL: 150 ppm VLE; 442 mg/m3 VLE France - VME: 100 ppm VME; 435 mg/m3 VME France - VLE: 150 ppm VLE; 650 mg/m3 VLE Germany: 100 ppm TWA; 440 mg/m3 TWA Germany: Skin absorber Japan: 50 ppm OEL; 217 mg/m3 OEL Malaysia: 199 ppm TWA; 434 mg/m3 TWA Netherlands: 50 ppm MAC; 210 mg/m3 MAC Russia: 50 mg/m3 TWA Spain: 50 ppm VLA-ED; 221 mg/m3 VLA-ED Spain: 100 ppm VLA-EC; 442 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Physical State: Liquid
Color: clear, colorless
Odor: aromatic odor
pH: Not applicable.
Vapor Pressure: 8.29 mm Hg @ 25 deg C
Viscosity: <32.6 SUS
Boiling Point: 136-140 deg C
Freezing/Melting Point: -34 deg C
Autoignition Temperature: 527 deg C ( 980.60 deg F)
Flash Point: 26.1 deg C ( 78.98 deg F)
Explosion Limits, lower: 1.1%
Explosion Limits, upper: 7.0%
Decomposition Temperature: Not available.
Solubility in water: Insoluble.
Specific Gravity/Density: 0.865 (water=1)
Molecular Formula: C8H10
Molecular Weight: 106.17

Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
High temperatures, ignition sources.
Incompatibilities with Other Materials:
Strong oxidizing agents, nitric acid.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

RTECS#:
CAS# 100-41-4: DA0700000 CAS# 1330-20-7: ZE2100000 LD50/LC50:
CAS# 100-41-4: Draize test, rabbit, eye: 500 mg Severe; Inhalation, mouse: LC50 = 35500 mg/m3/2H; Inhalation, rat: LC50 = 55000 mg/m3/2H; Oral, rat: LD50 = 3500 mg/kg; Oral, rat: LD50 = 3500 mg/kg; Skin, rabbit: LD50 = 17800 uL/kg.
CAS# 1330-20-7: Draize test, rabbit, eye: 87 mg Mild; Draize test, rabbit, eye: 5 mg/24H Severe; Draize test, rabbit, skin: 100% Moderate; Draize test, rabbit, skin: 500 mg/24H Moderate; Inhalation, rat: LC50 = 5000 ppm/4H; Oral, mouse: LD50 = 2119 mg/kg; Oral, rat: LD50 = 4300 mg/kg; Skin, rabbit: LD50 = >1700 mg/kg.
Carcinogenicity:
Ethylbenzene - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 6/11/04 IARC: Group 2B carcinogen Xylenes (o-, m-, p- isomers) - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Ecotoxicity:
Fish: Rainbow trout: LC50 = 13.5 mg/L; 96 Hr; UnspecifiedFish: Goldfish: LD50 = 13 mg/L; 24 Hr; UnspecifiedFish: Fathead Minnow: LC50 = 46 mg/L; 1 Hr; Static bioassayAcute and long-term toxicity to fish and invertebrates: LD50 for goldfish is 13 mg/L/24 Hr.
Cas#1330-20-7: LC50(96Hr.) rainbow trout = 8.05 mg/L, Static condition; LC50(96Hr.) fathead minnow = 16.1 mg/L, flow-through conditions; LC50(96Hr.) bluegill = 16.1 mg/L, flow-through; EC50 (48 Hr.) water flea = 3.82 mg/L, flow-through conditions; EC50(24 Hr.) photobacterium phosphoreum = 0.0084 mg/L, Microtox test.

Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

IATA
Shipping Name: XYLENES
Hazard Class: 3
UN Number: 1307
Packing Group: III
IMO
Shipping Name: XYLENES
Hazard Class: 3
UN Number: 1307
Packing Group: III
RID/ADR
Shipping Name: XYLENES
Hazard Class: 3
UN Number: 1307
Packing group: III
USA RQ: CAS# 100-41-4: 1000 lb final RQ; 454 kg final RQ
USA RQ: CAS# 1330-20-7: 100 lb final RQ; 45.4 kg final RQ

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 10 Flammable.
R 20/21 Harmful by inhalation and in contact with
skin.
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 25 Avoid contact with eyes.
WGK (Water Danger/Protection)
CAS# 100-41-4: 1
CAS# 1330-20-7: 2
Canada
CAS# 100-41-4 is listed on Canadas DSL List.
CAS# 1330-20-7 is listed on Canadas DSL List.
CAS# 100-41-4 is listed on Canadas Ingredient Disclosure List.
CAS# 1330-20-7 is not listed on Canadas Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 100-41-4 is listed on the TSCA inventory.
CAS# 1330-20-7 is listed on the TSCA inventory.